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KMID : 0381219750070030136
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Journal of RIMSK
1975 Volume.7 No. 3 p.136 ~ p.147
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Delayed Hypersensitivity
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Abstract
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The delayed type hypersensitivity skin reaction is only one of many manifestations of cellular immunity. This cellular immunity plays a major role in solid tissue allograft rejection, in the development of manifestations in some autoimmune diseases, in bodily defense against certain bacteria, certain viruses, and fungi, and in the defense against cancer (surveillance function).
The first step in the manifestation of delayed hypersensitivity is the interaction of the sensitized lymphocytes (T-cell) and the appropriate immunogen. As a result of such interaction, sensitized lymphocyte undergoes a blast transformation and consequently proliferate and differentiate into the lymphocytes. These serial changes are very important to expansion of the lymphocyte population. After contact with specific antigens, sensitised lymphocytes release the various kinds of lymphokines and contribute to subsequent cellular infiltration. The prototype of cell-mediated hypersensitivity and of "delayed" type skin reactions is seen in tuberculin hypersensitivity.
However, it is not known what type of molecule on the surface of the sensitized lymphocytes interacts with the antigenic determinants of the delayed type of hypersensitivity. This is one of the major unsolved problems of modern immunobiology.
In this part, it was discussed the some aspects of delayed type hypersensitivity and cellular immunity mainly on the basis reported recently about the physiochemical properties of lymphokines, general conceptions, relationships and role of cellular immunity to the various diseases and cancer.
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KEYWORD
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